Microwave-Assisted Synthesis of Fused and Substituted 2-Aminopyridines from β-Halo α,β-Unsaturated Aldehydes

Junali Gogoi; Pranjal Gogoi; Limi Goswami; Romesh C. Boruah

doi:10.1055/s-0034-1380516

Synthesis, Table of Contents

Synthesis 2015; 47(13): 1905-1912
DOI: 10.1055/s-0034-1380516

paper

Microwave-Assisted Synthesis of Fused and Substituted 2-Aminopyridines from β-Halo α,β-Unsaturated Aldehydes

Junali Gogoi

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India Email: gogoipranj@yahoo.co.uk Email: rc_boruah@yahoo.co.in

,

Pranjal Gogoi*

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India Email: gogoipranj@yahoo.co.uk Email: rc_boruah@yahoo.co.in

,

Limi Goswami

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India Email: gogoipranj@yahoo.co.uk Email: rc_boruah@yahoo.co.in

,

Romesh C. Boruah*

Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India Email: gogoipranj@yahoo.co.uk Email: rc_boruah@yahoo.co.in

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Abstract

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Abstract

2-Aminopyridines were synthesized from β-halo α,β-unsaturated aldehydes by a microwave-assisted Knoevenagel reaction. The β-halo-α,β-unsaturated aldehydes were, in turn, efficiently synthesized from the corresponding ketones by a Vilsmeier formylation reaction. The protocol was used to synthesize several novel steroidal and nonsteroidal fused 2-aminopyridine derivatives.

Key words

steroids - pyridines - enals - Knoevenagel reactions - cyclizations

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References

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